In vitro reports have revealed that sildenafil is selective for phosphodiesterase-five (PDE5) . Its effect is more strong on PDE5 than on other known phosphodiesterases . In particular, There exists a ten-situations selectivity more than PDE6 which happens to be associated with the phototransduction

Just like grapefruit, prescription drugs often known as cytochrome P450 (CP450) inhibitors and substrates can hold off the results of sildenafil and increase your likelihood of going through Uncomfortable side effects. CP450 inducers, for instance modafinil, lower the results of sildenafil if taken